bethkaora: Phobia The Usual Attack Women - Health, Medical ...

Phobia The Usual Attack Women - Health, Medical & Fitness ...

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Source: http://kitarebogli.blogspot.com/2013/01/phobia-usual-attack-women-health.html

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?? ?????? ????? ??? bethkaora ?? ???? ?:?? pm ??? ???? ??????? ???? ????!Twitter-? ??? ????Facebook-? ??? ????

Source: http://bethkaora.blogspot.com/2013/01/phobia-usual-attack-women-health.html

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Most-used diabetes drug works in different way than previously thought

Monday, January 7, 2013

A team, led by senior author Morris J. Birnbaum, MD, PhD, the Willard and Rhoda Ware Professor of Medicine, with the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, found that the diabetes drug metformin works in a different way than previously understood. Their research in mice found that metformin suppresses the liver hormone glucagon's ability to generate an important signaling molecule, pointing to new drug targets. The findings were published online this week in Nature.

For fifty years, one of the few classes of therapeutics effective in reducing the overactive glucose production associated with diabetes has been the biguanides, which includes metformin, the most frequently prescribed drug for type 2 diabetes. The inability of insulin to keep liver glucose output in check is a major factor in the high blood sugar of type 2 diabetes and other diseases of insulin resistance.

"Overall, metformin lowers blood glucose by decreasing liver production of glucose," says Birnbaum. "But we didn't really know how the drug accomplished that."

Imperfectly Understood

Despite metformin's success, its mechanism of action remained imperfectly understood. About a decade ago, researchers suggested that metformin reduces glucose synthesis by activating the enzyme AMPK. But this understanding was challenged by genetic experiments in 2010 by collaborators on the present Nature study. Coauthors Marc Foretz and Benoit Viollet from Inserm, CNRS, and Universit? Paris Descartes, Paris, found that the livers of mice without AMPK still responded to metformin, indicating that blood glucose levels were being controlled outside of the AMPK pathway.

Taking another look at how glucose is regulated normally, the team knew that when there is no food intake and glucose decreases, glucagon is secreted from the pancreas to signal the liver to produce glucose. They then asked if metformin works by stopping the glucagon cascade.

The Nature study describes a novel mechanism by which metformin antagonizes the action of glucagon, thus reducing fasting glucose levels. The team showed that metformin leads to the accumulation of AMP in mice, which inhibits an enzyme called adenylate cyclase, thereby reducing levels of cyclic AMP and protein kinase activity, eventually blocking glucagon-dependent glucose output from liver cells.

From this new understanding of metformin's action, Birnbaum and colleagues surmise that adenylate cyclase could be a new drug target by mimicking the way in which it is inhibited by metformin. This strategy would bypass metformin's affect on a cell's mitochondria to make energy, and possibility avoid the adverse side effects experienced by many people who take metformin, perhaps even working for those patients resistant to metformin.

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126152/Most_used_diabetes_drug_works_in_different_way_than_previously_thought

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How to cope with a slow connection away from home

8 hrs.

Whitson Gordon, Lifehacker

Q. ?I'm going home for the holidays, and my parents have a very slow connection. Do you have any tips for getting my work done effectively when everything's moving slower than molasses??

Separate your Internet-heavy work and postpone it?
A.?Before you start making tweaks to your browser and computer, it's a good idea to take stock of what work you have and separate it into two categories. GigaOM explains:

Divide your tasks into bandwidth-heavy and bandwidth-light. Evaluate your routine web tasks and see which ones you can do with a slow connection, and which ones require a faster, more reliable one. This is especially important if your mobile Internet provider charges based on bandwidth usage instead of time. Aliza Sherman did something similar in a previous post, to help her work around bandwidth limits.

This is particularly useful if you know you're going to be stuck on a slow connection, but even if you get yourself in a bind, you can still do some re-prioritization quickly. If you have some Internet-heavy tasks that can't wait, you should delegate them to someone else if you can???heck, even offer to pick up some of your co-workers' Internet-light load if they can help you out.

Tweak your browser for low-speed connections
Chances are, your browser isn't exactly primed for slow Internet speeds. So, we recommend grabbing a second browser that you can tweak to work better with slow connections. Opera is a great choice, because it has a Turbo Mode that optimizes the Web for faster loading, but no matter what, there are a number of tweaks you can make to speed up your browser, like:

With these few tweaks in place, you should find things run a little smoother and you won't be stuck waiting for pages quite as long.

Use mobile, HTML or other low-footprint sites
These days, a lot of websites load up their pages with junk that isn't really a problem when you have a normal high-speed connection, but can really bog things down when your connection is limited. Some of them have alternatives in place.?

Gmail, for example, has a handy HTML version that you can use to cut down on the crap when you need to get into your email quicker. You can also see if a specific site has a mobile version, designed for smartphones. Most mobile sites will only load if you're actually on a mobile device, though, so you'll want to change your browser's user agent to make sites recognize you as a smartphone.

Work outside your browser whenever possible
The?more you stay in your browser, the longer you'll be waiting for pages to load. Travel website Gadling recommends transferring as much of that work outside your browser as possible. For example, if you write on a blog or do any work in Google Docs, transfer that to a desktop app like Microsoft Office or LibreOffice for the time being. Heck, you can even compose an email in Notepad while you wait for it to load???don't waste any time watching a progress bar when you could be doing something else.

When you do have to work in your browser, try not to put too much stress on it. Open one tab at a time, so you aren't trying to load a bunch of pages at once (since it'll take them longer, and you can only read one at a time). Close tabs you aren't using often, as they can often take up bandwidth even if you aren't looking at them.

Turn off bandwidth-sucking background apps?
With all the focus on your browser, you may forget that other apps like Dropbox might be taking up precious bandwidth in the background. Close any and all of those you don't need to do your work, or put them into offline mode so they aren't constantly checking if they need to sync. Some apps may require some foresight for this to work: Notational Velocity and ResophNotes will work fine without a connection, for example, but Evernote will require you to go into its settings and download your notebooks before it'll work in offline mode.

When all else fails, find better Wi-Fi?
No one wants to rush around all day trying to find better Internet, but if what you're using is just too slow, look elsewhere. Free Wi-Fi is everywhere, and if at first you don't succeed, find a faster hotspot. You won't be able to do this all day if you have work to get done, but you should be able to find something that's somewhat workable for the time being.

More from Lifehacker:

Source: http://www.nbcnews.com/technology/technolog/how-deal-slow-internet-connection-away-home-1C7660214

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UK Newsx.com ? Use Online Marketing To Help Your Business ...

If you think about how pricey it can be to lease a billboard or hire telemarketers, online marketing really doesn?t cost very much. Not all methods of advertising on the internet are cheap, but enough are so that it is still the preferred option to advertise. Many businesses are not able to afford the price range of putting a banner ad on a popular site, but there are lots of ways to advertise that will fit in any budget. Search engines provide pay-per-click advertising, which is one of the most popular methods for marketing online. Online marketing is quick and effective, which is another major advantage.

With conventional types of advertising, it takes a while to be ready, but online it can happen in a few seconds or minutes. It will take days to get an advertisement in the paper, but almost immediately with an ad online. If online marketing was only fast and inexpensive it wouldn?t be worth the cost, but as it is also effective it is a fantastic deal. The majority of the people on the web consider online advertising to be trustworthy so you should have a good client base with which to connect. You?re wanting to come in contact with the most people you could who are part of your target audience. You are aiming to connect with people who want what you have for sale through the use of web marketing.

You could connect with a lot of people through the power of email marketing. Although you?ll get the best results when you send email to a list you personally created, you also have the option of paying for or renting lists. They?re not always that effective. One of the first things you are advised to do by many folks who make a living on the internet, is to get your own list of individuals you can email. So that you can speak with more people, you should set up a site. If you want to be visible online, you will require appealing, effective design combined with the best search engine optimization techniques. Take care not to excessively use keywords to keep the search engines from banning you due to spamming.

Using online marketing for web site advertising can be quite helpful. You?ll find an abundance of ways to interact with your prospective buyers worldwide. Even though there?s a lot to learn when it comes to internet marketing, the key to business success is online. Source: success formula

Source: http://www.uknewsx.com/use-online-marketing-to-help-your-business-earnings-explode/

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FTC scolds Apple, Google and developers over (lack of) kids' privacy

7 hrs.

Wilson Rothman , NBC News

Parents still aren't given the guidance they need to determine whether or not kids' apps are safe,?the?Federal Trade Commission said Monday.?

Comparing a new survey of kids' apps with its 2011 study, the FTC observed "little progress toward giving parents the information they need to determine what data is being collected from their children, how it is being shared, or who will have access to it." To make matters worse, in-app connections to?social media and mobile ad networks make tracking even more difficult, and even hard to identify by the developer itself.

"While we think most companies have the best intentions when it comes protecting kids' privacy, we haven't seen any progress,"?said FTC Chairman Jon Leibowitz, in a statement.?"In fact,?our study shows that kids' apps siphon an alarming amount of information from mobile devices without disclosing this fact to parents."

Also read:?iParenting: How I keep my kids safe around tablets

Under the FTC's?Children's Online Privacy Protection Act (COPPA), websites and online services must disclose that they collect and share information about children 12 or younger, and must get parental permission before gathering that information from kids. As Reuters reported in October,?the FTC is trying to update these ?rules to "further restrict companies and websites that target youths or are geared to young audiences."

To find out how the latest batch of kids' apps were doing, privacy-wise,?FTC staff examined hundreds?sold in both the Apple App Store and the Google Play store, the distribution point for most Android apps. Investigators sought out privacy?disclosure information in three locations: On the app store description page, inside the app itself and on the promotional Web page published by the?developer or publisher.

Beyond the fact that only 20 percent of reviewed apps disclosed "any information about the app's privacy practices,"?the FTC indicates there were some particular red flags.

"The results showed that many of the apps shared certain information with third parties???such as device ID, geolocation, or phone number ? without disclosing that fact to parents. Further, a number of apps contained interactive features ? such as advertising, the ability to make in-app purchases, and links to social media ? without disclosing these features to parents prior to download."

Nearly 60 percent of the studied apps were sending data back to the developer or an ad network, analytics firm or other third party.

When it comes to in-app purchases, 17 percent of the reviewed apps allowed kids to make?purchases at prices?ranging from 99 cents to $29.99. "Although both stores provided certain indicators when an app contained in-app purchasing capabilities, these indicators were not always prominent and, even if noticed, could be difficult for many parents to understand."

Although the study focused on individual apps, it's clear that the FTC holds Apple and Google responsible for the privacy protection of its app-buying?customers.?

"All of the companies in the mobile app space, especially the gatekeepers of the app stores, need to do a better job," said FTC Chairman?Leibowitz. "We'll do another survey in the future and we will expect to see improvement."

The?Association for Competitive Technology, an?advocacy group representing more than 5,000 app developers and IT firms, responded to the FTC report, saying "we still have a lot to do."

"For the past year, we have educated hundreds of app developers around the country on best practices for privacy and developed new transparency icons," said ACT?executive director Morgan Reed in an emailed statement.?"The message from the FTC today is that they appreciate our work, but we still have a lot to do."

Morgan did say that the FTC "missed" a few key?areas of progress, however.?

"Apple and the other platforms are moving developers away from using device-specific identifiers that can be unified across apps and services, and are introducing alternatives to limit tracking that are app-specific for sharing with advertisers and other third parties," he said. "This will make it very difficult to combine information based on these ID's across multiple apps or the Web."

He also pointed out that now, platforms are providing "very granular tools" in order to prevent apps from accessing geolocation and other certain data, regardless of the app itself.

The FTC says it would like to hear from parents who have complaints on this or any other issue concerning "fraudulent, deceptive, and unfair business practices," so feel free to reach out with your own concerns, either on?the?FTC's online?Complaint Assistant?or by calling 877-FTC-HELP (877-382-4357).

Wilson Rothman is the Technology & Science?editor at NBC News Digital. Catch up with him on Twitter at @wjrothman, and join our conversation on Facebook.

Source: http://www.nbcnews.com/technology/technolog/ftc-scolds-apple-google-developers-over-lack-kids-privacy-1C7527970

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Arthritis In Dogs Healing With Natural Treatments | ArticleBro.com

Dog owners are recommended to deviate from their regular habit of taking help of modern medicines to find perfect treatment for Arthritis in dogs. The prudent practice would to place reliance on natural treatments. With no sign of side-effects, this treatment option is the best remedy to get rid of arthritis symbols. Undoubtedly, the entire process could be a little time-consuming. However, once resorted to this kind of treatment, you are bound to get a permanent solution to your canine friend?s ill health. These natural treatments are powerful enough for healing this disorder without the treatment procedure becoming too painful.

Talking about natural ways to enhance Dogs Immune System, systematic and daily dosage of Glucosamine and Chondroitin Sulphate will be extremely helpful. Likewise, incorporating vitamins E, A, the MSM in the dog?s daily diet is a prudent move. For the prefect ailing of bones, you can serve home-cooked foods as well.

Keeping your dog on healthy diets brings improvement to its health condition. In other words, it goes a long way in boosting a stronger immunity system in them. As a consequence, they are better placed to fight any disease effortlessly. Alternatively, you can give them organic and natural food.

In absence of any specific treatment for this health condition, proper care and better health diet are the only two remedies presently available. Due to acute and chronic inflammation in the joints, it leads to restrictions in their movement and they are left to suffer in silence. This problem is very common among overweight and large breed of dogs.

Herbs such as Boswell can create wonder for improving this health condition. For, they are incredibly anti-inflammatory. To make sure that they have stronger joints and bones, you can take help of another herb named Alfalfa. Applying technique of acupuncture also yields great results.

Source: http://articlebro.com/2012/health-fitness/arthritis-in-dogs-healing-with-natural-treatments/

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The Right Way to go on a Low Carb Diet - Health & Fitness 368 ...

Diets that are low carb or even completely anti-carb are now among the most popular diets around. The notion that you should eat lots of protein and hardly any carbohydrates wasn't very widespread until the Atkins Diet came along. Although people who religiously followed such diets did lose weight, it was common for them to later gain it back because they were unable to maintain such a strict regimen of eating hardly any carbs at all. The fact is, you need some carbs to stay healthy.

They perform an essential function and provide your body with energy. The trick is to figure out how to eat a healthy amount of "good" carbs. We'll look at some ways to accomplish this.

When you must go out to eat, find something on the menu that is cooked by roasting. Fried or braised foods are mainly the menu items, but there should be a couple of roasted items for you to pick from. You can also look for side dishes like roasted vegetables. French fries can be traded in for roasted potatoes, but a salad would still be a better choice. Since you have chosen a low carb diet for getting healthier, you will want to choose roasted foods at a restaurant, because they don't involve oil, like fried or braised foods do.

Make salads your ally. There are lots of different types of salads out there so it's easy to find a salad that either fills you up completely or compliments your entree as a side dish. When eating salads, though, you have to be conscious of what kind of dressing you're using, and how much.

If you pour on globs of high fat dressing, that's probably also high in salt and sugar, you're undermining the healthy vegetables underneath. If you use a little bit of dressing, and it's a healthy one, you can enjoy the salad without guilt. You can research the many kinds of salads, and you can even invent new styles of your own; the same goes for dressings.

How do you feel about pasta? Are you worried about having to give it up? You may be assuming that pasta is incompatible with a low carbohydrate diet. Fortunately, this isn't the case. There are a lot of gluten free pastas out there now that you can use.

These are automatically lower in carbs and are better for your digestive system too. If you shop around you could even find veggie based pasta noodles. This will help you stay healthy, keep your carbs low and still allow you to indulge in one of your favorite foods. There are a lot of different things you can do to eat a lot less carbohydrates. It really isn't that difficult to eat a low carb diet. A low carb lifestyle needs a healthy start in order to make continuous progress, so talk to a doctor or qualified nutritionist to get on the right road in the beginning.

Source: http://healthfitness368.blogspot.com/2012/12/the-right-way-to-go-on-low-carb-diet.html

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Source: http://louannechase.typepad.com/blog/2012/12/the-right-way-to-go-on-a-low-carb-diet-health-fitness-368.html

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